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East Africa

🇸🇸 Vaccines for South Sudan

Entry requirements & recommendations for travel to South Sudan

South Sudan requires Yellow Fever vaccination for entry — a firm requirement for all travellers. Malaria is endemic at high risk throughout the country, making antimalarial medication essential. Hepatitis A, Typhoid, Hepatitis B, Meningococcal, and Rabies are also recommended. South Sudan, the world's newest country (independent since 2011), has experienced prolonged internal conflict since independence, and most governments advise against all travel — this is overwhelmingly the dominant consideration. Healthcare infrastructure is extremely limited, among the least developed in the world, reflecting the country's very recent formation and ongoing instability. Anyone travelling for essential humanitarian or professional purposes requires current, specific guidance well beyond general travel health information.

Medical disclaimer: This is general information only — not personal medical advice. Requirements and risks change. Always consult a qualified travel health clinic before departure.
Required for entry
Yellow Fever
Certificate required for all travellers.
💉 1 dose (lifetime)
📅 Book at least 3 weeks before travel
⚡ Effective: 10 days after vaccination. Certificate valid for life.
🛡 Protects for: Lifetime (single dose).
Required for entry
Recommended by WHO & CDC
Hepatitis A
Food and water contamination risk.
💉 2 doses
📅 Book at least 4 weeks before travel
⚡ Effective: 2 weeks after 1st dose. Full protection after 2nd dose (6–12 months later).
🛡 Protects for: 1st dose ~1 yr. 2nd dose: lifetime.
Recommended
Typhoid
Contaminated food and water.
💉 1 dose
📅 Book at least 3 weeks before travel
⚡ Effective: 2 weeks after vaccination.
🛡 Protects for: 3–5 years. Booster recommended if re-exposure.
Recommended
Hepatitis B
Blood and sexual contact.
💉 3 doses
📅 Book at least 26 weeks before travel
⚡ Effective: After full 3-dose course. Accelerated 3-week schedule available — ask your clinic.
🛡 Protects for: Lifetime after full course.
Recommended
Meningococcal
Meningitis belt.
💉 1 dose
📅 Book at least 3 weeks before travel
⚡ Effective: 2 weeks after vaccination.
🛡 Protects for: 5 years. Booster if ongoing risk.
Recommended
Rabies
Animal bites risk.
💉 3 doses
📅 Book at least 5 weeks before travel
⚡ Effective: After 3rd dose. 2nd dose 7 days after 1st, 3rd dose 21 days after 1st.
🛡 Protects for: Pre-exposure reduces post-bite treatment needed. Boosters based on blood tests.
Recommended
Disease risks
  • ⚠Malaria (high risk throughout)
  • ⚠Yellow Fever
  • ⚠Meningococcal disease
  • ⚠Ebola (border risk)
  • ⚠Cholera
Notes: Ongoing conflict — most governments advise against all travel. Yellow Fever required. Malaria prophylaxis essential.
Approximate cost per person
Required vaccines
~€74
(~$81)
per person · full courses
Yellow Fever (1 dose)€74 ($81)
Recommended vaccines
~€771
(~$840)
per person · full courses
Hepatitis A (2 doses)€140 ($152)
Typhoid (1 dose)€45 ($49)
Hepatitis B (3 doses)€189 ($207)
Meningococcal ACWY (1 dose)€60 ($65)
Rabies (3 doses)€273 ($297)
Malaria tablets (4 weeks) (1 dose)€64 ($70)

💡 Approximate figures based on private European travel clinic rates (April 2026). Actual costs vary by clinic and country. Not all recommended vaccines will apply to every trip — discuss your specific itinerary with a travel health clinic.

Often combined with
KenyaTanzaniaEthiopiaUganda
Common questions
Do I need vaccines for South Sudan?
Yellow Fever vaccination is required for entry for all travellers. Hepatitis A, Typhoid, Hepatitis B, Meningococcal, and Rabies are recommended, alongside essential malaria prophylaxis. However, these are secondary considerations to the overriding security situation — see the safety question.
Is there an Ebola risk in South Sudan?
South Sudan borders DR Congo, where Ebola has occurred in periodic outbreaks, and the situation should be checked via official sources before any travel given the porous nature of some border areas and limited surveillance capacity. This is a secondary consideration to South Sudan's own significant internal conflict, however.
Is there malaria in South Sudan?
Yes, malaria is endemic at high risk throughout South Sudan, and antimalarial medication would be essential for any visit, alongside the much more significant security considerations affecting the country.
Is it safe to travel to South Sudan?
No, according to most governments. South Sudan, independent since 2011, has experienced prolonged internal conflict, and advisories against all travel have been in place for an extended period. This is not a functioning tourism destination, and anyone needing to travel for essential humanitarian or professional purposes requires current, specific security guidance.