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East Africa

🇸🇸 Vaccines for South Sudan

Entry requirements & recommendations for travel to South Sudan

Yellow Fever required for entry. Malaria is endemic and antimalarials are essential. Meningococcal, Hepatitis A, Typhoid, and Rabies vaccines all recommended. Medical facilities are extremely limited. Most travel advisories currently advise against all but essential travel.

Medical disclaimer: This is general information only — not personal medical advice. Requirements and risks change. Always consult a qualified travel health clinic before departure.
Required for entry
Yellow Fever
Certificate required for all travellers.
💉 1 dose (lifetime)
📅 Book at least 3 weeks before travel
⚡ Effective: 10 days after vaccination. Certificate valid for life.
🛡 Protects for: Lifetime (single dose).
Required for entry
Recommended by WHO & CDC
Hepatitis A
Food and water contamination risk.
💉 2 doses
📅 Book at least 4 weeks before travel
⚡ Effective: 2 weeks after 1st dose. Full protection after 2nd dose (6–12 months later).
🛡 Protects for: 1st dose ~1 yr. 2nd dose: lifetime.
Recommended
Typhoid
Contaminated food and water.
💉 1 dose
📅 Book at least 3 weeks before travel
⚡ Effective: 2 weeks after vaccination.
🛡 Protects for: 3–5 years. Booster recommended if re-exposure.
Recommended
Hepatitis B
Blood and sexual contact.
💉 3 doses
📅 Book at least 26 weeks before travel
⚡ Effective: After full 3-dose course. Accelerated 3-week schedule available — ask your clinic.
🛡 Protects for: Lifetime after full course.
Recommended
Meningococcal
Meningitis belt.
💉 1 dose
📅 Book at least 3 weeks before travel
⚡ Effective: 2 weeks after vaccination.
🛡 Protects for: 5 years. Booster if ongoing risk.
Recommended
Rabies
Animal bites risk.
💉 3 doses
📅 Book at least 5 weeks before travel
⚡ Effective: After 3rd dose. 2nd dose 7 days after 1st, 3rd dose 21 days after 1st.
🛡 Protects for: Pre-exposure reduces post-bite treatment needed. Boosters based on blood tests.
Recommended
Disease risks
  • ⚠Malaria (high risk throughout)
  • ⚠Yellow Fever
  • ⚠Meningococcal disease
  • ⚠Ebola (border risk)
  • ⚠Cholera
Notes: Ongoing conflict — most governments advise against all travel. Yellow Fever required. Malaria prophylaxis essential.
Approximate cost per person
Required vaccines
~€74
(~$81)
per person · full courses
Yellow Fever (1 dose)€74 ($81)
Recommended vaccines
~€771
(~$840)
per person · full courses
Hepatitis A (2 doses)€140 ($152)
Typhoid (1 dose)€45 ($49)
Hepatitis B (3 doses)€189 ($207)
Meningococcal ACWY (1 dose)€60 ($65)
Rabies (3 doses)€273 ($297)
Malaria tablets (4 weeks) (1 dose)€64 ($70)

💡 Approximate figures based on private European travel clinic rates (April 2026). Actual costs vary by clinic and country. Not all recommended vaccines will apply to every trip — discuss your specific itinerary with a travel health clinic.

Often combined with
KenyaTanzaniaEthiopiaUganda
When to book

Book 8+ weeks before travel. Yellow Fever required. Malaria tablets need to start before travel. Full travel clinic consultation essential.

Common questions
Do I need vaccines for South Sudan?
Yellow Fever is required for entry. Malaria prevention is essential. Meningococcal, Hepatitis A, Typhoid, and Rabies are all recommended. South Sudan is a high-risk destination.
Is there an Ebola risk in South Sudan?
South Sudan is under elevated monitoring due to the 2026 DRC Ebola outbreak. Check current WHO and CDC alerts. US travellers returning from South Sudan must enter via designated airports for health screening.
Is there malaria in South Sudan?
Yes. Malaria is endemic throughout South Sudan. Antimalarials are essential for all visits.
Is it safe to travel to South Sudan?
Most governments advise against all but essential travel to South Sudan due to ongoing conflict and security risks.

Data based on WHO International Travel and Health and CDC Yellow Book 2026. Last verified: May 2026. Always verify current requirements with a travel health clinic before departure.