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Central Africa

🇸🇹 Vaccines for São Tomé and Príncipe

Entry requirements & recommendations for travel to São Tomé and Príncipe

Yellow Fever required for entry. Malaria is endemic and antimalarials are essential. Hepatitis A and Typhoid recommended.

Medical disclaimer: This is general information only — not personal medical advice. Requirements and risks change. Always consult a qualified travel health clinic before departure.
Required for entry
Yellow Fever
Certificate required if arriving from endemic country.
💉 1 dose (lifetime)
📅 Book at least 3 weeks before travel
⚡ Effective: 10 days after vaccination. Certificate valid for life.
🛡 Protects for: Lifetime (single dose).
Required for entry
Recommended by WHO & CDC
Hepatitis A
Food and water contamination risk.
💉 2 doses
📅 Book at least 4 weeks before travel
⚡ Effective: 2 weeks after 1st dose. Full protection after 2nd dose (6–12 months later).
🛡 Protects for: 1st dose ~1 yr. 2nd dose: lifetime.
Recommended
Typhoid
Contaminated food and water.
💉 1 dose
📅 Book at least 3 weeks before travel
⚡ Effective: 2 weeks after vaccination.
🛡 Protects for: 3–5 years. Booster recommended if re-exposure.
Recommended
Disease risks
  • ⚠Malaria (endemic throughout — prophylaxis essential)
  • ⚠Dengue
Approximate cost per person
Required vaccines
~€74
(~$81)
per person · full courses
Yellow Fever (1 dose)€74 ($81)
Recommended vaccines
~€249
(~$271)
per person · full courses
Hepatitis A (2 doses)€140 ($152)
Typhoid (1 dose)€45 ($49)
Malaria tablets (4 weeks) (1 dose)€64 ($70)

💡 Approximate figures based on private European travel clinic rates (April 2026). Actual costs vary by clinic and country. Not all recommended vaccines will apply to every trip — discuss your specific itinerary with a travel health clinic.

Often combined with
CameroonDR CongoRepublic of CongoCentral African Republic
When to book

Book 6–8 weeks before travel. Yellow Fever required for entry — certificate must be 10 days old. Malaria tablets need to start before travel.

Common questions
Do I need Yellow Fever vaccine for São Tomé and Príncipe?
Yes. Yellow Fever vaccination is required for entry. The certificate must be at least 10 days old on arrival.
Is there malaria in São Tomé and Príncipe?
Yes. Malaria is endemic on both islands. Antimalarials are essential for all visits.
Is tap water safe in São Tomé?
No. Use bottled water throughout.
What healthcare is available in São Tomé and Príncipe?
Medical facilities are very limited. Medical evacuation cover is essential.

Data based on WHO International Travel and Health and CDC Yellow Book 2026. Last verified: April 2026. Always verify current requirements with a travel health clinic before departure.