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Central Africa

🇨🇫 Vaccines for Central African Republic

Entry requirements & recommendations for travel to Central African Republic

Yellow Fever required for entry. Malaria is widespread and antimalarials are essential. Meningococcal, Hepatitis A, Typhoid, and Rabies vaccines all recommended. The security situation is serious across much of the country — this destination warrants a full travel clinic consultation.

Medical disclaimer: This is general information only — not personal medical advice. Requirements and risks change. Always consult a qualified travel health clinic before departure.
Required for entry
Yellow Fever
Certificate required for entry.
💉 1 dose (lifetime)
📅 Book at least 3 weeks before travel
⚡ Effective: 10 days after vaccination. Certificate valid for life.
🛡 Protects for: Lifetime (single dose).
Required for entry
Recommended by WHO & CDC
Hepatitis A
Food and water contamination risk.
💉 2 doses
📅 Book at least 4 weeks before travel
⚡ Effective: 2 weeks after 1st dose. Full protection after 2nd dose (6–12 months later).
🛡 Protects for: 1st dose ~1 yr. 2nd dose: lifetime.
Recommended
Typhoid
Contaminated food and water.
💉 1 dose
📅 Book at least 3 weeks before travel
⚡ Effective: 2 weeks after vaccination.
🛡 Protects for: 3–5 years. Booster recommended if re-exposure.
Recommended
Hepatitis B
Blood and sexual contact.
💉 3 doses
📅 Book at least 26 weeks before travel
⚡ Effective: After full 3-dose course. Accelerated 3-week schedule available — ask your clinic.
🛡 Protects for: Lifetime after full course.
Recommended
Meningococcal
Meningitis belt.
💉 1 dose
📅 Book at least 3 weeks before travel
⚡ Effective: 2 weeks after vaccination.
🛡 Protects for: 5 years. Booster if ongoing risk.
Recommended
Disease risks
  • ⚠Malaria (high risk)
  • ⚠Yellow Fever
  • ⚠Ebola (border risk)
  • ⚠Sleeping sickness
Approximate cost per person
Required vaccines
~€74
(~$81)
per person · full courses
Yellow Fever (1 dose)€74 ($81)
Recommended vaccines
~€498
(~$543)
per person · full courses
Hepatitis A (2 doses)€140 ($152)
Typhoid (1 dose)€45 ($49)
Hepatitis B (3 doses)€189 ($207)
Meningococcal ACWY (1 dose)€60 ($65)
Malaria tablets (4 weeks) (1 dose)€64 ($70)

💡 Approximate figures based on private European travel clinic rates (April 2026). Actual costs vary by clinic and country. Not all recommended vaccines will apply to every trip — discuss your specific itinerary with a travel health clinic.

Often combined with
CameroonDR CongoRepublic of CongoChad
When to book

Book 6–8 weeks before travel to Central African Republic. Yellow Fever certificate must be 10 days old on arrival. Malaria tablets need to start before travel — timing depends on which antimalarial you choose. Meningococcal, Hepatitis A and Typhoid can be done 2–4 weeks before departure.

Common questions
Do I need Yellow Fever vaccine for Central African Republic?
Yes. Yellow Fever vaccination is required for entry to Central African Republic. You must carry the International Certificate of Vaccination and it must be at least 10 days old on arrival.
Do I need malaria tablets for Central African Republic?
Yes. Malaria is endemic throughout Central African Republic. Antimalarials are essential for all visits. Discuss the right option with a travel clinic.
What other vaccines are needed for Central African Republic?
Meningococcal, Hepatitis A, Typhoid, and Rabies are recommended for Central African Republic. Ensure routine vaccinations are up to date before travel.
Is tap water safe in Central African Republic?
No. Do not drink tap water in Central African Republic. Use bottled water throughout your trip.

Data based on WHO International Travel and Health and CDC Yellow Book 2026. Last verified: April 2026. Always verify current requirements with a travel health clinic before departure.